SECTION: Chemistry
SCIENTIFIC ORGANIZATION:
Lomonosov Moscow State University, Faculty of Chemistry, Moscow, Russia

2G.R. Derzhavin Tambov State University, Tambov, Russia

3Eshelman School of Pharmacy, University of North Carolina-Chapel Hill, Chapel Hill, USA
REPORT FORM:
«Poster report»
AUTHOR(S)
OF THE REPORT:
M.M. Veselov1, P.G. Rudakovskaya1, A.G. Majouga1, M.V. Efremova1, I.V. Uporov1, Y.I. Golovin2, 1, N.L. Klyachko1, A.V. Kabanov3, 1
SPEAKER:
M.M. Veselov
REPORT TITLE:
New immobilization technique for nanomechanical control of biochemical reactions via low-frequency magnetic field
TALKING POINTS:

Magnetic nanoparticles can be used for nanomechanical control of biochemical properties of macromolecules via low-frequency non-heating magnetic field. It was shown [1] that super-low-frequency magnetic field (50Hz, 137,5 mTl) reduce the rate of enzyme activity of a-chymotrypsin, immobilized on copolymer-MNP aggregates, to 25%. We developed immobilized technique that achieves the less of enzyme activity to 55-60%. Also we studied the effect of AC magnetic field at different frequency and strength.
Reference:
1. Natalia L. Klyachko, Marina Sokolsky-Papkov, Nikorn Pothayee, Maria V. Efremova, Dmitry A. Gulin, Nipon Pothayee, Artem A. Kuznetsov, Alexander G. Majouga, Judy S. Riffle, Yuri I. Golovin, Alexander V. Kabanov. Angew. Chem. Int. Ed. 2012, 51, 12016 –12019